- The H1c haplotype at the MAPT locus is associated with Alzheimer's disease. Myers, A.J., Kaleem, M., Marlowe, L., Pittman, A.M., Lees, A.J., Fung, H.C., Duckworth, J., Leung, D., Gibson, A., Morris, C.M., de Silva, R., Hardy, J. Hum. Mol. Genet. (2005)