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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Brosimacutins J-M, four new flavonoids from Brosimum acutifolium and their cytotoxic activity.

Four new flavonoids, brosimacutins J-M (1 - 4), were isolated from the bark of Brosimum acutifolium Huber together with a known flavan, brosimine A (5). The structures of compounds 1-4 were elucidated by spectroscopic means. 27 constituents of this plant including compounds 1-5 were evaluated for their cytotoxic activity against murine leukemia P388 cells. Although no compounds tested had any reversal effect on vincristine resistance, brocimacutins J-M (1-4) were cytotoxic to vincristine-resistant P388 cells (IC50 4.4 - 19 microg/mL).[1]

References

  1. Brosimacutins J-M, four new flavonoids from Brosimum acutifolium and their cytotoxic activity. Takashima, J., Komiyama, K., Ishiyama, H., Kobayashi, J., Ohsaki, A. Planta Med. (2005) [Pubmed]
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