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Tiihonen, J. et al.

Tiihonen, Halonen, Wahlbeck, Repo-Tiihonen, Hyvärinen, Eronen, Putkonen, Takala, Mehtonen, Puck, Oksanen, Koskelainen, Joffe, Aer, Hallikainen, Ryynänen, Tupala,

Topiramate add-on in treatment-resistant schizophrenia: a randomized, double-blind, placebo-controlled, crossover trial.

OBJECTIVE: We tested the hypothesis that topiramate is more effective than placebo in reducing symptoms in patients with treatment-resistant schizophrenia when combined with ongoing antipsychotic medication. METHOD: Twenty-six hospitalized treatment-resistant patients with chronic DSM-IV-diagnosed schizophrenia participated in a randomized, double-blind, placebo-controlled trial in which 300 mg/day of topiramate was gradually added to their ongoing treatment (clozapine, olanzapine, risperidone, or quetiapine) over two 12-week crossover treatment periods. Data were collected from April 2003 to November 2003. RESULTS: In intention-to-treat analysis, topiramate was more effective than placebo in reducing Positive and Negative Syndrome Scale general psychopathologic symptoms (effect size = 0.7, p = .021), whereas no significant improvement was observed in positive or negative symptoms. CONCLUSION: Glutamate antagonist topiramate may be an effective adjuvant treatment in reducing general psychopathologic symptoms in patients with schizophrenia resistant to treatment with second-generation antipsychotics.[1]

References

Topiramate add-on in treatment-resistant schizophrenia: a randomized, double-blind, placebo-controlled, crossover trial. Tiihonen, J., Halonen, P., Wahlbeck, K., Repo-Tiihonen, E., Hyvärinen, S., Eronen, M., Putkonen, H., Takala, P., Mehtonen, O.P., Puck, M., Oksanen, J., Koskelainen, P., Joffe, G., Aer, J., Hallikainen, T., Ryynänen, O.P., Tupala, E. The Journal of clinical psychiatry. (2005) [Pubmed]

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