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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Inhibition of type II collagen induced arthritis in mice by an immunosuppressive extract of Tripterygium wilfordii Hook f.

The effects of Tripterygium wilfordii Hook f (TWHf), a Chinese herbal remedy, on type II collagen induced arthritis (CIA) in DBA/1LacJ mice were determined. Mice were divided into 4 groups receiving oral treatment for 63 days: Group A, sham feedings; Group B, TWHf (78 mg/day); Group C, TWHf (140 mg/day); Group D, TWHf (140 mg/day) starting 21 days after collagen immunization. Arthritis incidence was reduced and day of onset delayed in Groups B and C compared with A. Arthritic joint counts, arthritic severity scores, and anticollagen antibody titers were decreased in Groups B, C, and D compared with A. Histopathology revealed destructive arthritis only in Group A. Our results indicate that TWHf is a potent immunosuppressive inhibitor of CIA, even when treatment is begun 3 weeks after immunization.[1]

References

  1. Inhibition of type II collagen induced arthritis in mice by an immunosuppressive extract of Tripterygium wilfordii Hook f. Gu, W.Z., Brandwein, S.R., Banerjee, S. J. Rheumatol. (1992) [Pubmed]
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