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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Xu, J. et al.

Xu, Wei, Mathvink, Edmondson, Mastracchio, Eiermann, He, Leone, Leiting, Lyons, Marsilio, Patel, Petrov, Wu, Thornberry, Weber,

Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors.

anti-Substituted beta-methylphenylalanine derived amides have been shown to be potent DPP-IV inhibitors exhibiting excellent selectivity over both DPP8 and DPP9. The optimized compound exhibited good pharmacokinetic profiles in three preclinical species.[1]

References

Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors. Xu, J., Wei, L., Mathvink, R., Edmondson, S.D., Mastracchio, A., Eiermann, G.J., He, H., Leone, J.F., Leiting, B., Lyons, K.A., Marsilio, F., Patel, R.A., Petrov, A., Wu, J.K., Thornberry, N.A., Weber, A.E. Bioorg. Med. Chem. Lett. (2006) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg