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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Dystonia and the nuclear envelope.

Mutations in torsinA cause dominantly inherited early-onset torsion dystonia in humans. In this issue of Neuron, Goodchild et al. show that torsinA knockout and knockin mice have similar phenotypes, which suggests that the mutant torsinA allele causes disease because it has decreased function. The experiments also highlight the possible role of nuclear envelope dynamics in maintaining normal neuronal function.[1]


  1. Dystonia and the nuclear envelope. Cookson, M.R., Clarimon, J. Neuron (2005) [Pubmed]
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