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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Westermann, J. et al.

Jörg Westermann, Antje Lessen, Claudia Schlimper, Gökben Baskaynak, Philipp le Coutre, Bernd Dörken, Antonio Pezzutto,

Simultaneous cytokine analysis by cytometric bead array for the detection of leukaemia-reactive T cells in patients with chronic myeloid leukaemia.

In order to detect T cells against several chronic myeloid leukaemia (CML)-associated antigens we used: (i) a novel T-cell assay [cytometric bead array (CBA)]; (ii) gamma-interferon enzyme-linked immunoSPOT (gamma-IFN-ELISpot); and (iii) tetramer staining in peripheral blood from CML patients. Peptide-specific cytokine release was detected by CBA in some patients, whereas standard gamma-IFN-ELISpot and tetramer staining were negative in the vast majority of cases. In CBA, peptide-specific cytokine release was predominantly tumour necrosis factor-alpha, raising questions about the responding cells and their functional status. CBA appears to be a new useful tool for the detection of leukaemia-reactive T cells.[1]

References

Simultaneous cytokine analysis by cytometric bead array for the detection of leukaemia-reactive T cells in patients with chronic myeloid leukaemia. Westermann, J., Lessen, A., Schlimper, C., Baskaynak, G., le Coutre, P., Dörken, B., Pezzutto, A. Br. J. Haematol. (2006) [Pubmed]

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