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Bernitsas, E. et al.

Suppression of mitoxantrone cardiotoxicity in multiple sclerosis patients by dexrazoxane.

OBJECTIVE: To explore the potential of dexrazoxane to suppress subclinical cardiotoxicity in MS patients receiving mitoxantrone. METHODS: An open-label study was performed to evaluate possible subclinical cardiotoxicity in multiple sclerosis patients treated quarterly with mitoxantrone (48 mg/m(2) cumulative), with and without concomitant dexrazoxane, using blinded serial radionucleide ventriculography. RESULTS: No patient experienced symptoms of heart failure. Patients receiving dexrazoxane, which is cardioprotective for anthracyclines, exhibited a significantly lesser decline in left ventricular ejection fraction (mean change, -3.80% vs -8.55%, p < 0.001). INTERPRETATION: These results support a cardioprotective effect of dexrazoxane in mitoxantrone treated multiple sclerosis patients.[1]

References

Suppression of mitoxantrone cardiotoxicity in multiple sclerosis patients by dexrazoxane. Bernitsas, E., Wei, W., Mikol, D.D. Ann. Neurol. (2006) [Pubmed]

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