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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Head, E. et al.

Head, Barrett, Murphy, Das, Nistor, Sarsoza, Glabe, Kayed, Milton, Vasilevko, Milgram, Agadjanyan, Cribbs, Cotman,

Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta.

We describe a study testing fibrillar beta-amyloid(1-42) (Abeta42) vaccination in dogs. Three young beagles (4.6 years) were immunized twice with Abeta42 and a Th1 adjuvant (TiterMax Gold). Animals generated primarily IgG2 and IgM antibody responses, which were specific for the Abeta(11-30) region of Abeta(1-42). Next, 3 aged beagles (8.9-13.8 years) were immunized 4 times with Abeta(42) and a Th2 adjuvant (Alum). We observed an acute increase in IgG2, a slower increase in IgG1 and Abeta antibodies of broader specificity (Abeta(1-15>) Abeta(11-30>) Abeta(6-20)). A nonsignificant increase in CSF Abeta(1-40) and decrease in Abeta(1-40/1-42) in cortex was detected. Canines may be a useful system for testing an Abeta vaccine.[1]

References

Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta. Head, E., Barrett, E.G., Murphy, M.P., Das, P., Nistor, M., Sarsoza, F., Glabe, C.C., Kayed, R., Milton, S., Vasilevko, V., Milgram, N.W., Agadjanyan, M.G., Cribbs, D.H., Cotman, C.W. Vaccine (2006) [Pubmed]

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