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Harada, K.I. et al.

Effective treatment of coprophagia in a patient with schizophrenia with the novel atypical antipsychotic drug perospirone.

Here we report on a patient with schizophrenia who suffered from medication-refractory coprophagia. Although there were few cases in which psychotropic medication was effective against coprophagia, we encountered a patient with schizophrenia in whom coprophagia rapidly disappeared after treatment with perospirone, a novel atypical antipsychotic drug of the serotonin-dopamine antagonist (SDA) type. Perospirone has a uniquely high affinity for serotonin-1A receptors, and it could be speculated that perospirone, as a serotonin-1A receptor agonist combined with SDA, may have greater efficacy for treatment-refractory symptoms of schizophrenia. Thus, perospirone is an agent with possible efficacy for medication-refractory schizophrenia.[1]

References

Effective treatment of coprophagia in a patient with schizophrenia with the novel atypical antipsychotic drug perospirone. Harada, K.I., Yamamoto, K., Saito, T. Pharmacopsychiatry (2006) [Pubmed]

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