- The G397A (E133K) change in the AGGF1 (VG5Q) gene is a single nucleotide polymorphism in the Spanish population. Gutierrez, S., Magano, L., Delicado, A., Mori, M.A., de Torres, M.L., Fern??ndez, L., Palomares, M., Fern??ndez, E., Tarduchy, G.R., Molano, J., Gracia, R., Pajares, I.L., Lapunzina, P. Am. J. Med. Genet. A (2006)