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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Muscarinic receptor subtype in isolated dog and monkey facial vein.

Using the cannula inserting method, we investigated vascular responses to ACh and McN-A-343 (a M1-agonist) in isolated and perfused canine and simian facial veins in non-preconstricted conditions. ACh usually induced only a vasoconstriction, but McN-A-343 did not induce any significant vasoconstriction. It is concluded that canine and simian facial veins contain very few receptors of the muscarinic M1-subtype; and according to previous studies, these vessels have abundant M3-receptors.[1]


  1. Muscarinic receptor subtype in isolated dog and monkey facial vein. Chiba, S., Tsukada, M. Jpn. J. Pharmacol. (1991) [Pubmed]
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