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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Nieder, C. et al.

Carsten Nieder, Lu Cai, Wolfgang A. Weber, Sabine Schill, Nicolaus Andratschke, Markus Schwaiger, Michael Molls,

Evaluation of insulin-like growth factor-1 in a mouse model of long-term abdominal radiation toxicity.

The purpose of these experiments was to test whether a brief course of insulin-like growth factor-1 (IGF-1) injection (escalating doses) concomitant to irradiation ameliorates radiation-induced kidney dysfunction and lethal bowel toxicity in a mouse model of unilateral high-dose irradiation of the kidney and adjacent bowel. The kidney function was assessed by means of repeated 99mTc-dimercaptosuccinate scans (every six weeks) during a maximum follow-up of 49 weeks. The experiments with single fractions of 12 Gy and 15 Gy revealed only minor differences in the severity of kidney dysfunction and no reduction in lethal bowel toxicity from IGF-1 treatment In the absence of any significant radioprotective effect, other strategies of response modification need to be developed.[1]

References

Evaluation of insulin-like growth factor-1 in a mouse model of long-term abdominal radiation toxicity. Nieder, C., Cai, L., Weber, W.A., Schill, S., Andratschke, N., Schwaiger, M., Molls, M. Anticancer Res. (2007) [Pubmed]

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