- Juvenile Paget's disease: the second reported, oldest patient is homozygous for the TNFRSF11B "Balkan" mutation (966_969delTGACinsCTT), which elevates circulating immunoreactive osteoprotegerin levels. Whyte, M.P., Singhellakis, P.N., Petersen, M.B., Davies, M., Totty, W.G., Mumm, S. J. Bone Miner. Res. (2007)