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Ribatti, D. et al.

Ribatti, Poliani, Longo, Mangieri, Nico, Vacca,

Erythropoietin/erythropoietin receptor system is involved in angiogenesis in human neuroblastoma.

Aims: Previous studies have shown that increased vascularity is associated with tumour progression in human neuroblastoma ( NB). The involvement of erythropoietin (Epo) in tumour angiogenesis has also been reported. The aim of this study was to correlate microvascular density and Epo/Epo-receptor (EpoR) expression in endothelial and tumour cells to the clinical stage of NB. Methods and results: Specimens of NB obtained from 20 patients were investigated immunohistochemically by using anti-CD31, anti-Epo and anti-EpoR antibodies. The extent of angiogenesis was found to be up-regulated in advanced disease. In keeping with this observation, Epo/EpoR expression in tumour and endothelial cells, respectively, was also highly correlated with the extent of angiogenesis and higher clinical stage. Conclusions: The correlation of Epo/EpoR expression with angiogenesis and tumour progression suggests the presence of a loop in the Epo-EpoR system. Epo is secreted by tumour cells and affects vascular endothelial cells via its receptor, promoting tumour angiogenesis in a paracrine manner. Data suggest that Epo represents an important mediator in NB angiogenesis. Understanding the mechanisms of NB angiogenesis provides the basis for a rational approach to the development of antiangiogenic therapy in patients affected by NB.[1]

References

Erythropoietin/erythropoietin receptor system is involved in angiogenesis in human neuroblastoma. Ribatti, D., Poliani, P.L., Longo, V., Mangieri, D., Nico, B., Vacca, A. Histopathology (2007) [Pubmed]

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