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Lira, R.P. et al.

Rodrigo Pessoa Cavalcanti Lira, Luiz Felipe Lynch de Moraes, Mauro de Oliveira Júnior, Antônio Luiz Barbosa de Melo, Mirelle Souza Leão Vasconcelos,

Influence of bromopride in the prophylaxis of nausea associated with fluorescein angiography.

PURPOSES: To determine the efficacy of bromopride in the prophylaxis of nausea during fluorescein angiography, when compared with a placebo. METHODS: The study was a double-masked random clinical trial, between December of 2004 and April of 2005. Examinations were performed with 20% intravenous fluorescein sodium in a single dose of 2.5 ml. The patients were divided into two groups: group 1, patients who received a 2 ml intravenous dose of 5 mg/ml bromopride and group 2, patients who received a 2 ml intravenous dose of 0.9% sodium chloride (placebo), both 20 minutes before the dye injection. Cases of nausea were observed during and after the examination. RESULTS: 352 patients were enrolled, 176 in each group. Cases of nausea were observed in 12 (6.8%) patients of the bromopride group and in 11 (6.3%) patients of the placebo group (p<0.829 - relative risk=1.05). CONCLUSION: Bromopride did not prevent the occurrence of nausea in fluorescein angiography, when compared with a placebo.[1]

References

Influence of bromopride in the prophylaxis of nausea associated with fluorescein angiography. Lira, R.P., Moraes, L.F., Oliveira Júnior, M., Melo, A.L., Vasconcelos, M.S. Arq. Bras. Oftalmol (2007) [Pubmed]

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