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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Renal cell cancer and sorafenib: skin toxicity and treatment outcome.

We describe the case of a young man with refractory renal cell carcinoma who achieved an objective response in a metastatic lesion after biotherapy with the multikinase inhibitor sorafenib and also developed a severe skin reaction. The patient had been previously treated with various combinations of immunochemotherapy without any clinical benefit. We performed a brief review of the literature where similar cases were documented with the use of various anti-EGFR agents. The hypothesis of the correlation of skin toxicity with disease response is not new, but in the absence of any strong evidence remains controversial.[1]

References

  1. Renal cell cancer and sorafenib: skin toxicity and treatment outcome. Bajetta, E., Procopio, G., Verzoni, E., Catena, L., De Dosso, S., Platania, M., Gevorgyan, A. Tumori (2007) [Pubmed]
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