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Production of optically active 1,2,4-butanetriol from corresponding racemate by Microbial stereoinversion.

Sterigmatomyces elviae DSM 70852 produced 12 g/l (S)-1,2,4-butanetriol (enantiomeric excess >99.9%) from 20 g/l racemate in 82 h. From the results of the inversion of an (R)-isomer to an (S)-isomer and GC-MS, it was suggested that (R)-1,2,4-butanetriol is oxidized to 1,4-dihydroxy-2-butanone, which is reduced to an (S)-isomer.[1]

References

  1. Production of optically active 1,2,4-butanetriol from corresponding racemate by Microbial stereoinversion. Yamada-Onodera, K., Norimoto, A., Kawada, N., Furuya, R., Yamamoto, H., Tani, Y. J. Biosci. Bioeng. (2007) [Pubmed]
 
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