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Tfelt-Hansen, P. et al.

P. Tfelt-Hansen, L. Edvinsson,

Pharmacokinetic and pharmacodynamic variability as possible causes for different drug responses in migraine. A comment.

The pharmacokinetics of antimigraine drugs zolmitriptan and sumatriptan varied considerably with a fourfold to 10-fold variation in plasma levels. In addition, the pharmacodynamics of triptans as investigated in vitro also varied considerably. In theory, there should probably be a 10-fold variation in doses available, but in clinical practice a fourfold difference in doses will probably cover the needs of most patients.[1]

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Pharmacokinetic and pharmacodynamic variability as possible causes for different drug responses in migraine. A comment. Tfelt-Hansen, P., Edvinsson, L. Cephalalgia (2007) [Pubmed]

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