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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Safety of prolonged high-dose levofloxacin therapy for bone infections.

The records of 84 patients with bone infections treated with high-dose levofloxacin (i.e. 0.75-1g daily) for more than 4 weeks were reviewed. Patients were given either 500 mg b.i.d. throughout the treatment period [Group 1 (n=41)], 500 mg b.i.d. for 3 weeks and then 750 mg q.d. [Group 2 (n=21)] or 750 mg q.d. for the whole treatment period [Group 3 (n=22)]. All patients had combined therapy, including levofloxacin-rifampin in 62 cases (73.8%), for an average duration of 13.7 weeks. Muscular pain and/or tendonitis were reported in 19 patients (22.6%) which affected more patients in Groups 1 and 2 than in Group 3 (14/41 and 5/21 vs. 0/22; p=0.01 and 0.001, respectively). A dosage of 750 mg q.d. may be warranted for prolonged high-dose levofloxacin treatment in patients with bone infections rather than 500 mg b.i.d. for the entire duration of treatment, or for the first 3 weeks.[1]


  1. Safety of prolonged high-dose levofloxacin therapy for bone infections. Senneville, E., Poissy, J., Legout, L., Dehecq, C., Loïez, C., Valette, M., Beltrand, E., Caillaux, M., Mouton, Y., Migaud, H., Yazdanpanah, Y. J. Chemother (2007) [Pubmed]
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