Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Azizi, M. et al.

Michel Azizi, Costanza Emanueli, Severine Peyrard, Paolo Maddedu, François Alhenc-Gelas, Duncan J. Campbell,

Genetic and dietary control of plasma tissue kallikrein secretion and urinary kinins exretion in man.

OBJECTIVES: Tissue kallikrein is a major kinin-forming enzyme involved in artery and kidney functions. Urinary tissue kallikrein activity (UKLKa) reflects renal tissue kallikrein activity and depends on Na and K intake, and genetic factors, especially the tissue kallikrein-inactivating polymorphism, R53H. The effect of these factors on the level of kinin peptides is, however, not known. Moreover, a circulating form of tissue kallikrein is present in human plasma but its origin and regulation are unknown. METHODS: We used a crossover study to investigate UKLKa, plasma tissue kallikrein (pTK), and urinary kallidin peptides and metabolites (Uki) in 10 R53H and 30 R53R normotensive male subjects randomly assigned to either a 1-week low Na-high K or a high Na-low K diet. RESULTS: UKLKa was 50-60% lower in R53H than R53R subjects and was increased by the low Na-high K diet. pTK was also 45-55% lower in R53H than R53R subjects and was increased by the low Na-high K diet. Uki was slightly but significantly higher under the low Na-high K than the high Na-low K diet, but did not differ between genotypes. CONCLUSION: These observations indicate that pTK levels are genetically determined and regulated by Na and K diet, in parallel with UKLKa; this suggests that circulating tissue kallikrein originates mainly from the kidney, and can contribute to circulatory adaptation to dietary ions. Uki is influenced by the Na and K diet, suggesting that kinins participate in renal adaptation to ion intake, but do not quantitatively reflect tissue kallikrein activity in urine, or presumably, in the kidney.[1]

References

Genetic and dietary control of plasma tissue kallikrein secretion and urinary kinins exretion in man. Azizi, M., Emanueli, C., Peyrard, S., Maddedu, P., Alhenc-Gelas, F., Campbell, D.J. J. Hypertens. (2008) [Pubmed]

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