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Weinstock-Guttman, B. et al.

Bianca Weinstock-Guttman, Murali Ramanathan, Robert Zivadinov,

Interferon-beta treatment for relapsing multiple sclerosis.

BACKGROUND: Recombinant forms of IFN-beta were the first therapeutic intervention found to be effective at interfering with the course of multiple sclerosis (MS), a chronic and debilitating disease affecting the CNS in young adults. OBJECTIVE/METHODS: To examine the application of IFN-beta to MS treatment by a review of relevant literature. RESULTS: The different IFN-beta products available are similar in their clinical effects. However, the response to IFN-beta therapy is only partial and the most efficient individual-specific dose, route and frequency of administration are not elucidated fully. The mechanism of action of IFN-beta in MS is also not understood fully but its immunomodulatory effects are probably more important than its anti-proliferative and antiviral activities. CONCLUSIONS: Although new therapeutic approaches are being sought to better treat MS, IFN-beta remains one of the most recognized and approved worldwide therapeutic options for this disease.[1]

References

Interferon-beta treatment for relapsing multiple sclerosis. Weinstock-Guttman, B., Ramanathan, M., Zivadinov, R. Expert. Opin. Biol. Ther (2008) [Pubmed]

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