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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine.

Two novel SF5 analogs of the antimalarial agent mefloquine were synthesized in 5 steps and 10-23% overall yields and found to have improved activity and selectivity against malaria parasites. This work also represents the first report of SF5-substituted quinolines.[1]

References

  1. Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine. Wipf, P., Mo, T., Geib, S.J., Caridha, D., Dow, G.S., Gerena, L., Roncal, N., Milner, E.E. Org. Biomol. Chem. (2009) [Pubmed]
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