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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Mutiny on the Boun-T: controlling dangerous T cells through anergy.

In this review, I outline a current view of how T lymphocytes use extracellular signals to decide between activation and tolerance, and how the tolerant state is established and maintained at the molecular level. This decision is made by a series of intracellular proteins that actively oppose the induction of effector genes, and are inactivated by signals from costimulatory and/or growth factor receptors.[1]

References

  1. Mutiny on the Boun-T: controlling dangerous T cells through anergy. Wells, A.D. Discov. Med (2010) [Pubmed]
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