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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Structural study of phenyl boronic acid derivatives as AmpC beta-lactamase inhibitors.

A small set of boronic acids acting as low nanomolar inhibitors of AmpC beta-lactamase were designed and synthesized in the effort to improve affinity, pharmacokinetic properties, and to provide a valid lead compound. X-ray crystallography revealed the binary complex of the best inhibitor bound to the enzyme, highlighting possibilities for its further rational derivatization and chemical optimization.[1]

References

  1. Structural study of phenyl boronic acid derivatives as AmpC beta-lactamase inhibitors. Tondi, D., Calò, S., Shoichet, B.K., Costi, M.P. Bioorg. Med. Chem. Lett. (2010) [Pubmed]
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