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Bunik, V.I. et al.

Change in alpha-ketoglutarate dehydrogenase cooperative properties due to dihydrolipoate and NADH.

Reducing 2 SH-groups of KGD by dihydrolipoate leads to cooperativity in substrate binding. Cooperative properties of KGD in the KGD complex are modulated by NADH. Physiological significance of these observations is discussed.[1]

References

Change in alpha-ketoglutarate dehydrogenase cooperative properties due to dihydrolipoate and NADH. Bunik, V.I., Buneeva, O.A., Gomazkova, V.S. FEBS Lett. (1990) [Pubmed]

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