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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Change in alpha-ketoglutarate dehydrogenase cooperative properties due to dihydrolipoate and NADH.

Reducing 2 SH-groups of KGD by dihydrolipoate leads to cooperativity in substrate binding. Cooperative properties of KGD in the KGD complex are modulated by NADH. Physiological significance of these observations is discussed.[1]


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