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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The roles of Drosophila cyclins A and B in mitotic control.

We have cloned, sequenced, and characterized the expression of a Drosophila cyclin B gene. The independent evolutionary conservation of A- and B-type cyclins implies that they have distinct roles. Indeed, in mutant embryos deficient in cyclin A, cells that accumulate only cyclin B do not enter mitosis. Thus, in vivo, cyclin B is not sufficient for mitosis. Furthermore, we find that the two cyclins are coexpressed in all proliferating cells throughout development. Though lacking a formal demonstration that cyclin B is essential as it is in other organisms, we propose that each of these proteins fulfills a distinct and essential role in the cell cycle.[1]


  1. The roles of Drosophila cyclins A and B in mitotic control. Lehner, C.F., O'Farrell, P.H. Cell (1990) [Pubmed]
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