Role of disease risk scores in comparative effectiveness research with emerging therapies.
BACKGROUND: Usefulness of propensity scores and regression models to balance potential confounders at treatment initiation may be limited for newly introduced therapies with evolving use patterns. OBJECTIVES: To consider settings in which the disease risk score has theoretical advantages as a balancing score in comparative effectiveness research because of stability of disease risk and the availability of ample historical data on outcomes in people treated before introduction of the new therapy. METHODS: We review the indications for and balancing properties of disease risk scores in the setting of evolving therapies and discuss alternative approaches for estimation. We illustrate development of a disease risk score in the context of the introduction of atorvastatin and the use of high-dose statin therapy beginning in 1997, based on data from 5668 older survivors of myocardial infarction who filled a statin prescription within 30 days after discharge from 1995 until 2004. Theoretical considerations suggested development of a disease risk score among nonusers of atorvastatin and high-dose statins during the period 1995-1997. RESULTS: Observed risk of events increased from 11% to 35% across quintiles of the disease risk score, which had a C-statistic of 0.71. The score allowed control of many potential confounders even during early follow-up with few study endpoints. CONCLUSIONS: Balancing on a disease risk score offers an attractive alternative to a propensity score in some settings such as newly marketed drugs and provides an important axis for evaluation of potential effect modification. Joint consideration of propensity and disease risk scores may be valuable. Copyright © 2012 John Wiley & Sons, Ltd.[1]References
- Role of disease risk scores in comparative effectiveness research with emerging therapies. Glynn, R.J., Gagne, J.J., Schneeweiss, S. Pharmacoepidemiol. Drug. Saf (2012) [Pubmed]
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