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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A case series of lamotrigine increased to 300mg daily in patients with bipolar depression.

Bipolar depression is a condition lacking sufficient treatment options. While lamotrigine appears effective, clinical trials and prescribing guidelines address only daily doses below 300mg. METHODOLOGY: Thirteen consecutive outpatients with bipolar depression and taking 200mg of daily lamotrigine were openly administered a dose increased to 300mg and naturalistically followed. Study outcome was assessed by comparison of pre- and post-treatment Beck Depression Inventory (BDI) and Global Assessment of Functioning (GAF) scores. Stastical analysis applied the paired t-test. RESULTS: Increasing daily lamotrigine dose to 300mg was associated with good tolerability and significant improvement in BDI and GAF scores.[1]

References

  1. A case series of lamotrigine increased to 300mg daily in patients with bipolar depression. Abraham, P.F. Asian. J. Psychiatr (2011) [Pubmed]
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