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Weller, A. et al.

Endogenous cholecystokinin reduces feeding in young rats.

The hypothesis that endogenous cholecystokinin ( CCK) released from the small intestine during feeding causes satiety was tested in rat pups, 9 to 12 days old. Intragastric administration of soybean trypsin inhibitor, a procedure that releases CCK from the small intestine, decreased the subsequent intake of a test meal. This effect was reversed by prior treatment with MK-329, a selective antagonist of CCK at alimentary-type CCK (CCK-A) receptors. Thus, endogenous, small intestinal CCK can cause satiety in the neonatal rat and this effect involves CCK-A receptors.[1]

References

Endogenous cholecystokinin reduces feeding in young rats. Weller, A., Smith, G.P., Gibbs, J. Science (1990) [Pubmed]

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