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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Sequences of the cell-attachment sites of reovirus type 3 and its anti-idiotypic/antireceptor antibody: modeling of their three-dimensional structures.

Previous studies have identified an area of amino acid sequence similarity shared by the reovirus type 3 cell-attachment protein sigma 1 and an anti-idiotypic/antireceptor monoclonal antibody (mAb) 87.92.6 that mimics reovirus type 3 by attaching to the same cell-surface receptor. We found that synthetic peptides corresponding to this area of primary sequence similarity bind a neutralizing mAb 9BG5 against which the mAb 87.92.6 is directed. The synthetic peptides compete with mAb 87.92.6 and reovirus type 3 for binding by mAb 9BG5 and displace mAb 87.92.6 and reovirus type 3 from binding to the cell-surface reovirus type 3 receptor. Such observations show that the shared primary structure between reovirus type 3 sigma 1 polypeptide and antireceptor mAb 87.92.6 defines the oligopeptide neutralizing/cell-attachment epitope of reovirus type 3. Computer modeling of this epitope, by use of sequence similarities of known immunoglobulin hypervariable loop conformations, permits an examination of the rudimentary three-dimensional structure of this epitope.[1]

References

  1. Sequences of the cell-attachment sites of reovirus type 3 and its anti-idiotypic/antireceptor antibody: modeling of their three-dimensional structures. Williams, W.V., Guy, H.R., Rubin, D.H., Robey, F., Myers, J.N., Kieber-Emmons, T., Weiner, D.B., Greene, M.I. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
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