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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

The unexpected antitermination of gyrA-directed transcripts is enhanced by DNA relaxation.

We show that transcription originating at the gyrA promoter of Escherichia coli is less subject to termination at the lambda Toop terminator (22% read-through) than is transcription originating from either the galOP (1% read-through) or topA (3% read-through) control regions. Furthermore, termination of the gyrA transcripts decreases (60% read-through) upon relaxation of the template DNA. We believe that events related to stimulation of transcription at the gyrA promoter by DNA relaxation are responsible for the enhanced terminator read-through.[1]

References

  1. The unexpected antitermination of gyrA-directed transcripts is enhanced by DNA relaxation. Carty, M., Menzel, R. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
 
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