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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A yeast and a human CCAAT-binding protein have heterologous subunits that are functionally interchangeable.

The S. cerevisiae HAP2 and HAP3 gene products have been shown to recognize CCAAT-containing transcription elements as a HAP2/HAP3 multisubunit heterologous complex, or heteromer. Recently, we have demonstrated that the human sequence-specific DNA-binding protein, CP1, also recognizes CCAAT-containing transcription elements as a heteromer. Mammalian cells contain at least three distinct CCAAT-binding proteins, all of which appear to be multisubunit complexes composed of heterologous subunits. One of these proteins, CP1, has DNA-binding properties that are virtually identical to the yeast HAP2/HAP3 complex. These two proteins bind to the same target sequences, make the same DNA contacts, and are affected in a similar manner by mutations in the CCAAT element. Most surprisingly, the subunits of CP1 and HAP2/HAP3 are functionally interchangeable. That is, the yeast/human hybrid complexes that are formed retain the ability to specifically recognize CCAAT elements.[1]


  1. A yeast and a human CCAAT-binding protein have heterologous subunits that are functionally interchangeable. Chodosh, L.A., Olesen, J., Hahn, S., Baldwin, A.S., Guarente, L., Sharp, P.A. Cell (1988) [Pubmed]
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