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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Double-blind trial of naproxen and phenylbutazone in ankylosing spondylitis.

In a double-blind double-placebo crossover study naproxen (500-750 mg daily) was found to be equivalent to phenylbutazone (400-600 mg daily) in the control of disease activity in 20 patients suffering from ankylosing spondylitis during a two times 5-week trial period. No serious side effects were observed during the trial period. Gastric complaints occurred twice as often under phenylbutazone as under naproxen.[1]


  1. Double-blind trial of naproxen and phenylbutazone in ankylosing spondylitis. Van Gerwen, F., Van der Korst, J.K., Gribnau, F.W. Ann. Rheum. Dis. (1978) [Pubmed]
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