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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Arrangement of the disulphide bridges in human low-Mr kininogen.

The arrangement of the disulphide bridges in human low-Mr kininogen has been elucidated. Low-Mr kininogen contains 18 half-cystine residues forming nine disulphide bridges. The first and the last half-cystine residues of the amino acid sequence form a disulphide loop which spans the heavy- and the light-chain portion of the kininogen molecule. The other 16 half-cystine residues are linked consecutively to form eight loops of 4-20 amino acids; these loops are lined up in the heavy-chain portion of the kininogen molecule. In this way, a particular pattern of disulphide loops is formed which seems to be of critical importance for the inhibitor function of human kininogen.[1]


  1. Arrangement of the disulphide bridges in human low-Mr kininogen. Kellermann, J., Thelen, C., Lottspeich, F., Henschen, A., Vogel, R., Müller-Esterl, W. Biochem. J. (1987) [Pubmed]
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