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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cholestatic hepatic injury related to warfarin exposure.

Despite the widespread use of oral anticoagulants derived from 4-hydroxycoumarin, there have been only a small number of well-defined cases of hepatotoxicity. We report a well-defined case of cholestasis following exposure to warfarin sodium (Coumadin). Inadvertent rechallenge reproduced the syndrome. Cholestasis may occur in response to exposure to derivations of 4-hydroxycoumarin.[1]


  1. Cholestatic hepatic injury related to warfarin exposure. Adler, E., Benjamin, S.B., Zimmerman, H.J. Arch. Intern. Med. (1986) [Pubmed]
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