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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Tourette syndrome and HLA.

Five kindreds with multiple individuals manifesting Tourette syndrome (TS) or related abnormal movements were evaluated for linkage between TS and HLA-A, B, C and DR antigens. Families were selected to have a constellation of affected individuals which gave the appearance of transmission of a major susceptibility gene. All kindreds had at least two clearly affected first or second degree relatives. Although developmental neurobehavioral disorders are candidates for showing a relationship to specific tissue antigens, we found no evidence for a close linkage between a gene locus determining susceptibility to TS and the HLA loci.[1]

References

  1. Tourette syndrome and HLA. Caine, E.D., Weitkamp, L.R., Chiverton, P., Guttormsen, S., Yagnow, R., Hempfling, S., Kennelly, D. J. Neurol. Sci. (1985) [Pubmed]
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