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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Reciprocal biological activities of the cyclic tetrapeptides chlamydocin and HC-toxin.

Chlamydocin, a potent cytostatic agent against cultured mammalian cells, and HC-toxin, a host-specific phytotoxin, are cyclic tetrapeptides containing the same epoxide alpha-amino acid. We show here that these compounds have reciprocal biological activity; HC-toxin is cytostatic against cultured mastocytoma cells, and chlamydocin has host-specific toxin activity against maize. Chlamydocin and another related cyclic peptide, Cyl-2, are less host-specific than HC-toxin because maize tolerant to HC-toxin is more sensitive to chlamydocin and Cyl-2.[1]


  1. Reciprocal biological activities of the cyclic tetrapeptides chlamydocin and HC-toxin. Walton, J.D., Earle, E.D., Stähelin, H., Grieder, A., Hirota, A., Suzuki, A. Experientia (1985) [Pubmed]
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