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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

L-Proline inhibition of glutamate release.

The influence of 1 mM-L-proline on electrically stimulated release of endogenous glutamate from slices of rat frontal cortex was measured. One mM-L-proline approximates the in vitro concentration that inhibits glutamate-induced spreading depression. Also, this L-proline level has been reported to be present in brain after an intraperitoneal injection that induced amnesia in chicks. L-Proline but not D-proline exhibits an inhibitory effect on glutamate release, thus supporting the suggestion that this mechanism may play a role in memory retention and/or formation.[1]

References

  1. L-Proline inhibition of glutamate release. Keller, E., Davis, J.L., Tachiki, K.H., Cummins, J.T., Baxter, C.F. J. Neurochem. (1981) [Pubmed]
 
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