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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Early morning insomnia with rapidly eliminated benzodiazepines.

Early morning insomnia, a significant increase in wakefulness during the final hours of drug nights, occurred after 1 or 2 weeks of nightly administration of benzodiazepine hypnotics with short elimination half-lives, when tolerance had begun to develop. Early morning insomnia may be a variant of rebound insomnia and therefore specific to benzodiazepines, or it may occur with any rapidly eliminated sedative-hypnotic agent.[1]

References

  1. Early morning insomnia with rapidly eliminated benzodiazepines. Kales, A., Soldatos, C.R., Bixler, E.O., Kales, J.D. Science (1983) [Pubmed]
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