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Neuropeptide Y in phaeochromocytomas and ganglioneuroblastomas.

Tumour tissue from nineteen patients with phaeochromocytomas and nine with ganglioneuroblastomas contained large numbers of neuropeptide Y ( NPY) producing cells and extracts of these tumours had very high concentrations of immunoreactive NPY. Plasma NPY concentrations were also raised, averaging 460 pmol/l in patients with tumours of the sympathetic chain and 55 pmol/l in healthy controls. Since plasma NPY is straightforward to measure and relatively stable, its estimation may prove helpful as a screening tests for phaeochromocytoma.[1]

References

  1. Neuropeptide Y in phaeochromocytomas and ganglioneuroblastomas. Adrian, T.E., Allen, J.M., Terenghi, G., Bacarese-Hamilton, A.J., Brown, M.J., Polak, J.M., Bloom, S.R. Lancet (1983) [Pubmed]
 
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