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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Effective treatment of advanced multiple myeloma refractory to alkylating agents.

Twenty-nine patients with advanced refractory multiple myeloma were treated with intermittent high-dose dexamethasone in combination with four-day infusions of vincristine and doxorubicin. Rapid and marked tumor-mass reduction (greater than 75 per cent) was noted in 14 of 20 patients whose disease was resistant to alkylating agents and in 3 of 9 patients with additional resistance to doxorubicin--a result far superior to those in previous trials with similar patients. In responsive patients, remissions were of excellent quality, and survival was significantly longer than in unresponsive patients.[1]

References

  1. Effective treatment of advanced multiple myeloma refractory to alkylating agents. Barlogie, B., Smith, L., Alexanian, R. N. Engl. J. Med. (1984) [Pubmed]
 
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