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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Acute tumor lysis in T-cell leukemia induced by amsacrine.

The acridine orange derivative amsacrine (National Services Center No. 249992) was used to treat a patient with T-cell acute lymphoblastic leukemia (ALL). A 17-year-old boy had a tumor lysis syndrome after a single 200 mg/sq m dose of amsacrine. This was followed by a prolonged period of marrow hypoplasia leading to death from infection. Review of the literature and our own experience would suggest that T-cell ALL may be exquisitely sensitive to amsacrine.[1]

References

  1. Acute tumor lysis in T-cell leukemia induced by amsacrine. Vogler, W.R., Morris, J.G., Winton, E.F. Arch. Intern. Med. (1983) [Pubmed]
 
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