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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Metabolism of the anticancer agent 1-(4-acetylphenyl)-3,3-dimethyltriazene.

High pressure liquid chromatography was used in combination with mass spectrometry to confirm that the main products of in vitro metabolism of 1-(4-acetylphenyl)-3,3-dimethyltriazene are 1-(4-acetylphenyl-3-methyltriazene and 4-aminoacetophenone. In addition a novel metabolite, 1-[4-(1-hydroxyethyl)-phenyl]-3,3-dimethyltriazene, possessing antitumour activity similar to the parent drug, was identified.[1]

References

  1. Metabolism of the anticancer agent 1-(4-acetylphenyl)-3,3-dimethyltriazene. Farina, P., Benfenati, E., Reginato, R., Torti, L., D'Incalci, M., Threadgill, M.D., Gescher, A. Biomed. Mass Spectrom. (1983) [Pubmed]
 
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