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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Sparteine oxidation by the human liver: absence of inhibition by mephenytoin.

Recent population data suggest independence of the genetic polymorphisms in mephenytoin and sparteine/debrisoquine oxidation. We used human liver preparations to test whether mephenytoin competes with sparteine for binding to the genetically variable cytochrome P-450, which mediates metabolism of both sparteine and debrisoquine. Mephenytoin failed to inhibit in vitro sparteine oxidation. This provides biochemical evidence that the polymorphism of sparteine/debrisoquine metabolism is not related to that of mephenytoin.[1]


  1. Sparteine oxidation by the human liver: absence of inhibition by mephenytoin. Jurima, M., Inaba, T., Kalow, W. Clin. Pharmacol. Ther. (1984) [Pubmed]
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