The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Topographical distribution of coated pits.

The internalization of a wide range of biologically significant macromolecules, particularly low density lipoproteins (LDL) and proteins such as alpha 2-macroglobulin and epidermal growth factor, occurs primarily through characteristic, bristle-coated indentations of the cell surface known as coated pits. Current interest has focused on the topographical relationship between surface receptors for these ligands and the coated pits. We establish here that coated pits are themselves distributed non-randomly on the J774.2 mouse macrophage cell surface. Morphometric and statistical analyses of cell profiles in electron micrographs indicate two levels of asymmetry; in all cells, pits are clustered; after colchicine treatment they accumulate over a microvillous protuberance that develops at one pole of the cell. This topographical heterogeneity suggests a new level at which cellular responses to growth substances and hormones may be regulated.[1]

References

  1. Topographical distribution of coated pits. Pfeiffer, J.R., Oliver, J.M., Berlin, R.D. Nature (1980) [Pubmed]
 
WikiGenes - Universities