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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The interaction with tubulin of a series of stilbenes based on combretastatin A-4.

A series of stilbenes, based on combretastatin A-4, were synthesised. A structure-activity study was carried out to characterise the interaction of these agents with tubulin. The substitution of small alkyl substituents for the 4'-methoxy group of combretastatin A-4 and the loss of the 3'-hydroxyl group does not have a major effect on the interaction with tubulin. trans-Stilbenes were shown to bind tubulin, but do not inhibit microtubule assembly. This work, together with previous studies, has been used to propose an idealised structure for a tubulin-binding agent of this type.[1]

References

  1. The interaction with tubulin of a series of stilbenes based on combretastatin A-4. Woods, J.A., Hadfield, J.A., Pettit, G.R., Fox, B.W., McGown, A.T. Br. J. Cancer (1995) [Pubmed]
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