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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer.

We treated 19 patients with advanced breast cancer resistant to tamoxifen with a new specific antioestrogen (ICI 182780) which, in animal studies, has no agonist activity. 13 (69%) patients responded (7 had partial responses and 6 showed no change) to monthly intramuscular injections of ICI 182780 after progression on tamoxifen, for a median duration of 18 months with minimum side effects. Preliminary evidence suggests that the agent is without effects on the liver or the hypothalamic-pituitary axis. ICI 182780 appears to be a promising new agent for treatment of advanced and early breast cancer.[1]

References

  1. Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer. Howell, A., DeFriend, D., Robertson, J., Blamey, R., Walton, P. Lancet (1995) [Pubmed]
 
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