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Sellers, A.J. et al.

Activation of BKCa channels in acutely dissociated neurones from the rat ventromedial hypothalamus by NS 1619.

NS 1619 activates the large-conductance Ca(2+)-dependent K+ channel (BKCa) in membrane patches isolated from rat ventromedial hypothalamic neurones. The activation is concentration dependent, with a maximal effect at less than 30 microM, reversible and can be inhibited by application of iberiotoxin to the extracellular membrane. NS 1619 does not activate ATP-K+ channels present in the same neurones.[1]

References

Activation of BKCa channels in acutely dissociated neurones from the rat ventromedial hypothalamus by NS 1619. Sellers, A.J., Ashford, M.L. Br. J. Pharmacol. (1994) [Pubmed]

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