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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Study of anticancer drug interaction with DNA by means of particle-induced desorption mass spectrometry: prospydine and deoxyguanosine-5'-monophosphate.

Using 252CF particle desorption mass spectrometry, the interaction between an antitumour drug prospydine (Pro) and deoxyguanosine-5'-monophosphate (pdG) has been studied. The adduct which corresponds to a peak at m/z 524.5 and which occurs as a result of the particular degradation of Pro during its alkylating of pdG has been found.[1]

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